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Avizafone
Avizafone is a unique water—soluble prodrug of diazepam, developed for emergency medical care. Originally created for military use, it serves as an antidote for poisoning with nerve agents. Rapidly converting to diazepam in the body, Avizafone provides effective treatment in critical situations. Evaluate the power of science in action with an Avizaphone. You can buy…
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Description
Avizafone is a unique water—soluble prodrug of diazepam, developed for emergency medical care. Originally created for military use, it serves as an antidote for poisoning with nerve agents. Rapidly converting to diazepam in the body, Avizafone provides effective treatment in critical situations. Evaluate the power of science in action with an Avizaphone.
Product Overview:
Avizafone, also known as prodiazepam, is a water-soluble prodrug of diazepam. Developed by the French military, it is used primarily as an antidote for poisoning with organophosphate nerve agents.
Mechanism of action:
After oral administration, Avizafone is rapidly metabolized in the liver, turning into diazepam. It is part of a combination therapy that includes an anticholinergic agent and an acetylcholinesterase reactivator to neutralize the effects of nerve agents.
Method of administration and dosage:
The recommended dose of Avizafone for organophosphate poisoning is 20 mg. It is prescribed in combination with other specific antidotes.
Side effects and safety:
Side effects are similar to those of diazepam and may include amnesia, anxiety, gastrointestinal disorders, and others. However, given its use in life-threatening situations, these effects are considered less significant.
Reducing harm and addiction:
Since Avizafone is intended for single use in critical situations, the risk of abuse and addiction is minimal. Common harm reduction strategies when using benzodiazepines include avoiding combination with other depressants and strict adherence to prescribed dosages.
Technical Information:
Product Name: Avizafone
Synonyms: Avizafone HCL, Pro-Diazepam
CAS: 65617-86-9
IUPAC: 8-bromo-6-(2-chlorophenyl)-1-methyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepine
Molecular Formula: C22H27ClN4O3
Molecular Weight: 430.9 g/mol
Purity: 98.0 % min.
Formulations: A crystalline solid
Solubility:
- DMSO: soluble
- Ethanol: soluble
InChI: InChI=1S/C22H27ClN4O3/c1-27(20(28)14-26-22(30)18(25)9-5-6-12-24)19-11-10-16(23)13-17(19)21(29)15-7-3-2-4-8-15/h2-4,7-8,10-11,13,18H,5-6,9,12,14,24-25H2,1H3,(H,26,30)/t18-/m0/s1
InChIKey: LTKOVYBBGBGKTA-SFHVURJKSA-N
SMILES: CN(C1=C(C=C(C=C1)Cl)C(=O)C2=CC=CC=C2)C(=O)CNC(=O)C(CCCCN)N
Storage: -20°C
Stability: ≥ 4 years
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